NoName_3327 → N-(3-(4-Amino-6-methyl-1,3,5-triazin-2-YL)-5-methylpyridine-2-YL)-1H-indazol-4-amine

HRID 1811829

Reaktionsgleichung

Reaktionsgleichung von HRID 1811829
Cl[C:2]1[C:7]([C:8]2[N:13]=[C:12]([CH3:14])[N:11]=[C:10]([NH2:15])[N:9]=2)=[CH:6][C:5]([CH3:16])=[CH:4][N:3]=1.[NH:17]1[C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([NH2:26])[C:20]=2[CH:19]=[N:18]1>>[NH2:15][C:10]1[N:11]=[C:12]([CH3:14])[N:13]=[C:8]([C:7]2[C:2]([NH:26][C:21]3[C:20]4[CH:19]=[N:18][NH:17][C:25]=4[CH:24]=[CH:23][CH:22]=3)=[N:3][CH:4]=[C:5]([CH3:16])[CH:6]=2)[N:9]=1

Komponenten

3

Edukt 2

HCID 413085NoName_3327HCID 595482414-(2-Chloro-5-methylpyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

Produkt 1

HCID 49786007N-(3-(4-Amino-6-methyl-1,3,5-triazin-2-YL)-5-methylpyridine-2-YL)-1H-indazol-4-amine

Versuchsvorschrift

The experimental procedure for this compound was the same as Example 22, Step 2 using 4-(2-chloro-5-methylpyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine and 1H-indazol-4-amine. LCMS (API-ES) m/z 333 (M+H)+. 1H NMR (400 MHz, d6-DMSO) δ 13.08 (d, J=2.35 Hz, 1H); 12.12 (br. s., 1H); 8.64 (br. s., 1H); 8.28 (dd, J=3.81, 2.05 Hz, 1H); 8.14 (d, J=5.28 Hz, 2H); 7.74 (br. s., 2H); 7.31 (d, J=7.63 Hz, 1H); 7.32 (br. s., 1H); 7.13 (d, J=12.91 Hz, 1H); 3.32 (d, J=1.37 Hz, 6H).

Quellen und Nachweise

ORD-Eintrag
ord-25de454caaf849648e02a69dd8781234
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362241B2

Verknüpfte Notizen

Wird geladen…