Tetrahydrofuran → HCID 22502706, Verbindung

Reaktionsgleichung

C(N1CCN([C:9]2[C:14]3[CH:15]=[CH:16][S:17][C:13]=3[CH:12]=[C:11]([C:18]3[CH:23]=[CH:22][C:21]([CH:24]=[O:25])=[CH:20][CH:19]=3)[N:10]=2)CC1)C.C([Mg]Br)C.[CH2:30]([O:32]CC)[CH3:31].[Cl-].[NH4+].[O:37]1CCCC1>>[O:32]1[CH2:30][CH2:31][O:25][CH:24]1[C:21]1[CH:20]=[CH:19][C:18]([C:11]2[NH:10][C:9](=[O:37])[C:14]3[CH:15]=[CH:16][S:17][C:13]=3[CH:12]=2)=[CH:23][CH:22]=1

Komponenten

Edukt 4

HCID 8028Tetrahydrofuran

HCID 25517Ammonium Chloride

HCID 22502581HCID 22502581, Verbindung

HCID 178467792HCID 178467792, Verbindung

Produkt 1

HCID 22502706HCID 22502706, Verbindung

Versuchsvorschrift

To a solution of 4-(4-ethylpiperazin-1-yl)-6-(4-formylphenyl)thieno-[3,2-c]pyridine (0.20 g) in tetrahydrofuran (20 ml) was added 3M ethylmagnesium bromide/diethyl ether solution (0.5 ml), and the mixture was reacted at room temperature for 30 min. To the resulting reaction solution was added an aqueous solution of ammonium chloride, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried. The resulting product was filtered through NH silica gel and washed with ethyl acetate. The filtrate was concentrated, to give 0.17 g of the title compound as white crystals.