Dimethylamine → N,N-Dimethyl 3-nitrobenzenesulfonamide

HRID 1814645

Reaktionsgleichung

Reaktionsgleichung von HRID 1814645
[N+:1]([C:4]1[CH:5]=[C:6]([S:10](Cl)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH3:14][NH:15][CH3:16]>C1COCC1>[CH3:14][N:15]([CH3:16])[S:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)(=[O:12])=[O:11]

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 84763-Nitrobenzenesulfonyl chloride

Produkt 1

HCID 224495N,N-Dimethyl 3-nitrobenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

3-Nitrobenzenesulfonyl chloride (22.8 mmol, 5.05 g) was dissolved in dry THF (50 mL). Dimethylamine in THF (2M, 34 mL) was added and the mixture was refluxed for 2 hours. Upon cooling, the mixture was filtered and the filtrate was evaporated in vacuo. The residue was dissolved in ethyl acetate (250 mL), washed with water (3×50 mL) and dried over MgSO4. Evaporation of the solvent afforded the title compound.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperatureUpon cooling
  3. filtrationthe mixture was filtered
  4. customthe filtrate was evaporated in vacuo
  5. dissolutionThe residue was dissolved in ethyl acetate (250 mL)
  6. washwashed with water (3×50 mL)
  7. dry with materialdried over MgSO4
  8. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-89cc37bfb4614153853c214b9f65ea8c
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06875760B2

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