Hydrochloric Acid → 2-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)

HRID 1814740Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1814740
C(OC(=O)[NH:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])(C)(C)C.[ClH:18]>O1CCOCC1>[ClH:18].[NH2:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 10538259tert-Butyl [2-(morpholin-4-yl)-2-oxoethyl]carbamate

Produkt 1

HCID 122918142-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)Ausbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a stirred solution of the above (2-morpholin-4-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester (0.44 g, 1.8 mmol) in 1,4-dioxane (4.0 mL), HCl (4.0 mL of a 4 M solution in 1,4-dioxane) was added at room temperature. After one h, the precipitated product was collected via filtration and washed with EtOAc. The solid was dried under high vacuum to give 0.23 g (76%) of 2-amino-1-morpholin-4-yl-ethanone hydrochloride which was used without further purification.

Aufarbeitung

  1. filtrationAfter one h, the precipitated product was collected via filtration
  2. washwashed with EtOAc
  3. customThe solid was dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-83fba8d2fdac469082f67417fadf52a3
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06878706B1

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