Allyl bromide → 3-Bromo-4-fluorophenyl allyl ether

HRID 1815812

Reaktionsgleichung

Reaktionsgleichung von HRID 1815812
[Br:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].[CH2:10](Br)[CH:11]=[CH2:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Br:1])[CH:3]=1)[CH:11]=[CH2:10]

Komponenten

5

Edukt 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 27833813-Bromo-4-Fluorophenol

Produkt 1

HCID 221447733-Bromo-4-fluorophenyl allyl etherAusbeute 61 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 0.65 gm (3.43 mMol) 3-bromo-4-fluorophenol, 0.60 mL (6.86 mMol) allyl bromide, and 0.71 gm (5.15 mMol) potassium carbonate in 6 mL acetone was stirred at reflux for 13 hours. The reaction mixture was concentrated under reduced pressure and the residue subjected to silica gel chromatography, eluting with hexane. Fractions containing product were combined and concentrated under reduced pressure to provide 61% of the desired compound.

Aufarbeitung

  1. temperatureat reflux for 13 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. washeluting with hexane
  4. additionFractions containing product
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5ee9e77b515b49c19f3f69c2293207d2
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06881733B1

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