Hydrochloric Acid → HCID 69745334, Verbindung

HRID 1815846Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1815846
C(OC([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[C:16]([O:23][CH3:24])[CH:15]=2)[C@H:10]([CH3:25])[CH2:9]1)=O)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[CH3:25][C@H:10]1[C@@H:11]([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[C:16]([O:23][CH3:24])[CH:15]=2)[CH2:12][CH2:13][NH:8][CH2:9]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 69745095HCID 69745095, Verbindung

Produkt 1

HCID 69745334HCID 69745334, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of 0.30 gm cis-1-(tert-butoxycarbonyl)-3-methyl-4-(5-methoxybenzofur-7-yl)piperidine in 10 mL 4N hydrochloric acid in dioxane is stirred at room temperature for 1 hour. The reaction mixture is concentrated under reduced pressure and the white solid residue is dried under reduced pressure at 60° C. for about 16 hours to provide 0.16 gm (96%) of the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customthe white solid residue is dried under reduced pressure at 60° C. for about 16 hours

Quellen und Nachweise

ORD-Eintrag
ord-ba308e3f7b324e1aac6b5e6190778cfe
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06881733B1

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