HCID 22495688, Verbindung → HCID 69744908, Verbindung

HRID 1815856Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1815856
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[CH:16][C:15]=2[F:23])[CH:10]([CH2:25][CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1CCC(OC(=O)C(C)=O)(C2C3OC=CC=3C=CC=2F)C(CC)C1)C1C=CC=CC=1>>[CH2:1]([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[CH:16][C:15]=2[F:23])[C@H:10]([CH2:25][CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 22495688HCID 22495688, VerbindungHCID 22495710HCID 22495710, Verbindung

Produkt 1

HCID 69744908HCID 69744908, VerbindungAusbeute 95,1 %

Versuchsvorschrift

Beginning with 5.4 gm (15.3 mMol) 1-benzyl-3-ethyl-4-hydroxy-4-(6-fluorobenzofur-7-yl)piperidine, 5.91 gm (88%) 1-benzyl-3-ethyl-4-(methyl oxoacetoxy)-4-(6-fluorobenzofur-7-yl)piperidine was recovered as an orange oil, essentially as described in EXAMPLE 16. This material was treated with tri(n-butyl)tin hydride essentially as described in EXAMPLE 16 to provide 4.91 gm of the desired compound.

Aufarbeitung

  1. customwas recovered as an orange oil
  2. additionThis material was treated with tri(n-butyl)tin hydride essentially

Quellen und Nachweise

ORD-Eintrag
ord-9bf9289dffec4f1ea2a8aee263834dc3
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06881733B1

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