Potassium Carbonate → HCID 15510116, Verbindung

HRID 1816201Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1816201
[NH2:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([C:9]([F:12])([CH3:11])[CH3:10])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:19]1([CH2:25][CH2:26][CH2:27][CH:28]([NH2:32])[CH:29]2[CH2:31][CH2:30]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(#N)C>[NH2:1][C:2]1[N:3]=[C:4]([C:9]([F:12])([CH3:11])[CH3:10])[N:5]=[C:6]([NH:32][CH:28]([CH:29]2[CH2:31][CH2:30]2)[CH2:27][CH2:26][CH2:25][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:7]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 114468284-Chloro-6-(2-Fluoropropan-2-Yl)-1,3,5-Triazin-2-AmineHCID 17958117α-Cyclopropylbenzenebutanamine

Produkt 1

HCID 15510116HCID 15510116, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

1.52 g (0.008 mol) of 2-amino-4-chloro-6-(1-fluoro-1-methylethyl)-1,3,5-triazine and 1.64 g (0.012 mol) of potassium carbonate are introduced into 30 ml of acetonitrile. 1.50 g (0.008 mol) of 4-phenyl-1-cyclopropyl-1-butylamine, dissolved in 10 ml of acetonitrile, are added dropwise to this solution. The mixture is refluxed for three hours. The solid components are then filtered off with suction and the filtrate is evaporated on a rotary evaporator. The residue is purified by column chromatography (eluant: methyl acetate). This gives 2.36 g (86% of theory) of 2-amino-4-(1-fluoro-1-methylethyl)-6-(1-phenyl-4-cyclopropyl-4-butylamino)-1,3,5-triazine.

Aufarbeitung

  1. additionare added dropwise to this solution
  2. temperatureThe mixture is refluxed for three hours
  3. filtrationThe solid components are then filtered off with suction
  4. customthe filtrate is evaporated on a rotary evaporator
  5. customThe residue is purified by column chromatography (eluant: methyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-a7e79d39029f466e8e98e27f53e1c200
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06884758B2

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