4-Cyclohexylcyclohexanol → (1,1'-Bicyclohexyl)-4-one

Temperatur

0 °C

To a solution of 4-hydroxycyclohexylcyclohexane (25 g) in acetone (250 ml) was added dropwise with stirring 2.67N Jone's regend (77 ml) at 0° C. The mixture was then stirred for 1 hour at 0° C. The organic layer was collected and evaporated. The reaction mixture was added to a mixture of water and diethyl ether. The organic layer was washed with water, sodium hydrogen carbonate solution and brine. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was concentrated under reduced pressure to give 4-cyclohexylcyclohexanone (19.57 g).

1. stirringThe mixture was then stirred for 1 hour at 0° C
2. customThe organic layer was collected
3. customevaporated
4. additionThe reaction mixture was added to a mixture of water and diethyl ether
5. washThe organic layer was washed with water, sodium hydrogen carbonate solution and brine
6. dry with materialdried over magnesium sulfate
7. filtrationThe magnesium sulfate was filtered off
8. concentrationthe filtrate was concentrated under reduced pressure

ORD-Eintrag

ord-6538edd7f04946fca2640004d114912b

Quelldatensatz

uspto-grants-2005_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06884774B2