m-Chloroperbenzoic acid → HCID 69801129, Verbindung

HRID 1816591Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1816591
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([O:10]O)=[O:9])[CH:3]=1.[CH:12]([O:15][CH:16]([CH2:22][C:23]1[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18])([CH3:14])[CH3:13]>ClCCl.C(=O)([O-])O.[Na+]>[C:8]([O-:10])(=[O:9])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:2][CH2:3][CH2:4]/[CH:3]=[CH:2]\[CH2:7][CH2:6][CH2:27][CH2:28][CH2:23][CH2:22][CH2:16][CH3:17].[CH2:20]([O:19][C:17](=[O:18])[CH:16]([O:15][CH:12]([CH3:14])[CH3:13])[CH2:22][C:23]1[CH:24]=[CH:25][NH+:26]=[CH:27][CH:28]=1)[CH3:21]

Komponenten

5

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 22494133HCID 22494133, Verbindung

Produkt 1

HCID 69801129HCID 69801129, VerbindungAusbeute 119,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 516892Sodium BicarbonateLösungsmittel

Versuchsvorschrift

6.0 g of m-chloroperbenzoic acid was added to a solution of 4.88 g ethyl 2-isopropoxy-3-(4-pyridyl)propanoate in dichloromethane (50 mL), followed by stirring at room temperature for 1.5 hours. After the reaction solution was diluted with saturated aqueous sodium hydrogencarbonate solution, the aqueous layer was extracted with dichloromethane for 3 times. The combined organic layer was dried over anhydrous sodium sulfate and then concentrated, to give 6.40 g crude 4-(3-ethoxy-2-isopropoxy-3-oxopropyl)-1-pyridinium oleate as a yellow oil.

Aufarbeitung

  1. extractionthe aqueous layer was extracted with dichloromethane for 3 times
  2. dry with materialThe combined organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-32c0ad75e1a344c8abb11f739e7a6914
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06884821B1

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