Sodium Hydroxide → 1-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine

HRID 1816741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1816741
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][C:19]([O:28][CH3:29])([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>C(O)C>[CH3:29][O:28][C:19]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:18][CH2:17][N:16]([C:13]2[CH:12]=[CH:11][C:10]([N:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)=[CH:15][CH:14]=2)[CH2:21][CH2:20]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 224947141-Acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine

Produkt 1

HCID 224946521-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazineAusbeute 97,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1-acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.5 g) and 10% NaOH aq. (10.2 ml) in ethyl alcohol (50 ml) was refluxed for 23.5 hours. The reaction mixture was evaporated under reduced pressure. The residue was washed with water, and dried to give 1-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.18 g).

Aufarbeitung

  1. temperaturewas refluxed for 23.5 hours
  2. customThe reaction mixture was evaporated under reduced pressure
  3. washThe residue was washed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-817354e23e2d4fe7b375eb987f56526b
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06884868B1

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