1,4-Dioxane → 6-Chloroquinoline-2-carbaldehyde

HRID 1817068

Reaktionsgleichung

Reaktionsgleichung von HRID 1817068
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[CH:5]2.[O:13]1CCOCC1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH:12]=[O:13])[CH:6]=[CH:5]2

Komponenten

3

Edukt 2

HCID 312751,4-DioxaneHCID 1359656-Chloroquinaldine

Produkt 1

HCID 2712836-Chloroquinoline-2-carbaldehyde

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A suspension of 6-chloro-2-methyl-quinoline (355 mg) and SeO2 (233 mg) in 1,4-dioxane (3 mL) was heated at 80° C. for 16 h. The resulting black mixture was filtered through diatomaceous earth. Concentration of the filtrate gave the title compound as a yellow powder (324 mg).

Aufarbeitung

  1. filtrationThe resulting black mixture was filtered through diatomaceous earth

Quellen und Nachweise

ORD-Eintrag
ord-1bd9952abc354bf7b6e36cdafa038914
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07598249B2

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