1-Butanol → 1-(Glycyloxy)butane chloride

HRID 1817299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1817299
Cl.[NH2:2][CH2:3][C:4]([OH:6])=[O:5].S(Cl)([Cl:9])=O.[CH2:11](O)[CH2:12][CH2:13][CH3:14]>>[Cl-:9].[NH2:2][CH2:3][C:4]([O:6][CH2:11][CH2:12][CH2:13][CH3:14])=[O:5]

Komponenten

4

Edukt 3

HCID 2631-ButanolHCID 22316Glycine HydrochlorideHCID 24386Thionyl Chloride

Produkt 1

HCID 866139031-(Glycyloxy)butane chloride

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a suspension of glycine hydrochloride (10 g, 89.6 mmol) in 250 mL butanol under nitrogen was added thionyl chloride (45.7 mL, 627 mmol) dropwise. After the addition was complete, the solution was heated at 70° C. overnight. The volatile components were removed on the roto-evaporator and the residue was suspended and evaporated from toluene three times. The resulting crude gum was dissolved in an equal weight of toluene for easy transfer and was used as is in the next reaction.

Aufarbeitung

  1. additionAfter the addition
  2. customThe volatile components were removed on the roto-evaporator
  3. customevaporated from toluene three times
  4. dissolutionThe resulting crude gum was dissolved in an equal weight of toluene for easy transfer
  5. customas is in the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-491dd942da334ab9a9e0643ea6bc3180
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07598264B2

Notizen zur Reaktion

Wird geladen…