Diethylamine → 6-[(3-chloro-4-fluoro-phenyl)methyl]-N,N-diethyl-4-hydroxy-2-methyl-3,5-dioxo-7,8-dihydro-2,6-naphthyridine-1-carboxamide

HRID 1817341Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1817341
[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[F:28])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([O:22]C)[C:10](=[O:21])[N:11]([CH3:20])[C:12]=2[C:16]([O:18]C)=O)[C:7]1=[O:24].[CH2:29]([NH:31][CH2:32][CH3:33])[CH3:30]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[F:28])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:22])[C:10](=[O:21])[N:11]([CH3:20])[C:12]=2[C:16]([N:31]([CH2:32][CH3:33])[CH2:29][CH3:30])=[O:18])[C:7]1=[O:24]

Komponenten

3

Edukt 2

HCID 8021DiethylamineHCID 69058384Methyl 6-(3-chloro-4-fluorobenzyl)-4-methoxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

Produkt 1

HCID 546818736-[(3-chloro-4-fluoro-phenyl)methyl]-N,N-diethyl-4-hydroxy-2-methyl-3,5-dioxo-7,8-dihydro-2,6-naphthyridine-1-carboxamide

Versuchsvorschrift

The title compound was prepared from methyl 6-(3-chloro-4-fluorobenzyl)-4-methoxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate in a manner similar to that described in Example 12, Steps 12, 13 and 14, using diethyl amine in place of dimethylamine in the step corresponding to Step 13 of Example 12.

Quellen und Nachweise

ORD-Eintrag
ord-7c90e7c47941423ba112e40a61765455
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07598264B2

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