2-cyano-N-(pyridin-4-ylmethyl)acetamide → (E,E)-2-((Pyridin-4-ylmethyl)aminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile

HRID 1818048

Reaktionsgleichung

Reaktionsgleichung von HRID 1818048
[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[OH:12])[CH:5]=[CH:6][CH:7]=O.[C:13]([CH2:15][C:16]([NH:18][CH2:19][C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)=[O:17])#[N:14]>>[N:23]1[CH:24]=[CH:25][C:20]([CH2:19][NH:18][C:16](/[C:15](=[CH:7]/[CH:6]=[CH:5]/[C:4]2[CH:9]=[CH:10][C:11]([OH:12])=[C:2]([OH:1])[CH:3]=2)/[C:13]#[N:14])=[O:17])=[CH:21][CH:22]=1

Komponenten

3

Edukt 2

HCID 3048762-cyano-N-(pyridin-4-ylmethyl)acetamideHCID 4430343-(3,4-Dihydroxy-phenyl)-2-propenal

Produkt 1

HCID 11631146(E,E)-2-((Pyridin-4-ylmethyl)aminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile

Versuchsvorschrift

The compound was prepared as described in Example 3 by adding 3,4-dihydroxycinnamaldehyde (32 mg, 0.2 mmol) to 2-cyano-N-pyridin-4-ylmethylacetamide (33 mg, 0.2 mmol). After refluxing for 2 h and recrystallization from ethanol-water an orange solid was obtained (44 mg, 69%). The product gave the following analytical data:

Aufarbeitung

  1. customThe compound was prepared
  2. temperatureAfter refluxing for 2 h
  3. customrecrystallization from ethanol-water an orange solid
  4. customwas obtained (44 mg, 69%)
  5. customThe product gave the following analytical data

Quellen und Nachweise

ORD-Eintrag
ord-169dfcbb2f974101bb7f118e44164be2
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07598419B2

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