HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Pyridinylboronic acid → 1-isobutyl-8-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Edukt | 8-bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine | HCID 11174597 | — |
| Produkt | 1-isobutyl-8-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine | HCID 21984046 | — |
Reaktionsschritte
8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and pyridine-3-boronic acid were coupled according to the general procedure described in Part J of Example 1. Purification by chromatography on silica gel (7%-10% methanol in CH2Cl2 gradient) afforded 1-isobutyl-8-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. 244-246° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07598382B2 |
| Quelldatensatz | uspto-grants-2009_10 |
| ORD ID | ord-cf401aa0ad084bdbbb1546d68106edf0 |
| Quellennotiz | uspto-grants-2009_10 |