3-Methoxypropylamine → (7-Bromo-3-nitroquinolin-4-yl)-(3-methoxypropyl)amine
Reaktionsgleichung
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](Cl)=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:16][O:17][CH2:18][CH2:19][CH2:20][NH2:21]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:21][CH2:20][CH2:19][CH2:18][O:17][CH3:16])=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
7-Bromo-4-chloro-3-nitroquinoline (29.54 g, 102.7 mmol) was reacted with 3-methoxy propyl amine (10.07 g, 113.0 mmol) according to the method described in Part A of Examples 125-135 to provide 32.9 g of (7-bromo-3-nitroquinolin-4-yl)-(3-methoxypropyl)amine as a yellow solid. The product was not recrystallized.
Quellen und Nachweise
- ORD-Eintrag
- ord-0577e3a026534b0f825b9a02214d4dce
- Quelldatensatz
- uspto-grants-2009_10