Hydrogen Peroxide → 3-[4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidin-1-yl]benzamide

HRID 1819363Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1819363
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:15]3[CH2:19][N:18]([C:20]4[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=4)[C:23]#[N:24])[C:17](=[O:28])[CH2:16]3)[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+].OO.[OH:33]S(O)(=O)=O>C(O)C>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:15]3[CH2:19][N:18]([C:20]4[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=4)[C:23]([NH2:24])=[O:33])[C:17](=[O:28])[CH2:16]3)[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:2][CH2:3][CH2:4][CH2:5]1

Komponenten

6

Edukt 4

HCID 784Hydrogen PeroxideHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 104746693-[4-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-oxo-pyrrolidin-1-yl]benzonitrile

Produkt 1

HCID 99525243-[4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidin-1-yl]benzamideAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To 12.5 mg of benzonitrile 42 (0.033 mmol) in 0.5 mL of ethanol was added 2 μL of a 25% NaOH solution followed by 29 μL of 35% H2O2. The temperature of the reaction mixture was kept at 50° C. for 3 h. Upon completion, 5% H2SO4 was added until the mixture was neutral (pH 7). The reaction mixture was extracted with EtOAc and dried with MgSO4. Concentration and purification of the residue by column chromatography on silica gel gave the desired product as a white solid. Yield: 94%.

Aufarbeitung

  1. extractionThe reaction mixture was extracted with EtOAc
  2. dry with materialdried with MgSO4
  3. concentrationConcentration and purification of the residue by column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-88e8c44520e545a69ea098041476cfb7
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07601742B2

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