HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 182Erstellt: 23. Oktober 2026
Methylamine hydrochloride → N-methyl-5-(trifluoromethyl)pyridin-3-amine
https://huagongshe.com/de/reaction/182
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Methylamine hydrochloride | HCID 6364545 | — |
| Edukt | 3-Bromo-5-(trifluoromethyl)pyridine | HCID 11127991 | — |
| Reagenz | Cesium carbonate | HCID 10796 | — |
| Katalysator | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Katalysator | Palladium, tris[mu-[(1,2-eta:4,5-eta)-(1E,4E)-1,5-diphenyl-1,4-pentadien-3-one]]di-, compd. with trichloromethane (1:1) | HCID 11029508 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | N-methyl-5-(trifluoromethyl)pyridin-3-amine | HCID 21221268 | 0% |
Reaktionsschritte
3-bromo-5-(trifluoromethyl)pyridine (100 mg, 0.44 mmol), methylamine hydrochloride (59.8 mg, 0.88 mmol), and cesium carbonate (490 mg, 1.50 mmol) were suspended in dioxane (3 mL) . The reaction was purged with nitrogen for 30 minutes then 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene (7.68 mg, 0.01 mmol) and TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM(0)-CHLOROFORM ADDUCT (9.16 mg, 8.85 µmol) were added. The reaction was heated to 130 °C in a CEM microwave for 1 hour. No Product formed. Abandoned
Herkunft & Nachweise
| Quelldatensatz | 750 AstraZeneca ELN dataset |
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| ORD ID | ord-6058a506bcd3404d8683ad593ff991cd |
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| Quellennotiz | 750 AstraZeneca ELN dataset |
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