4-(4-Chlorophenyl)-4-hydroxypiperidine → N-(1-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-4-(methylthio)-1-oxobutan-2-yl)benzamide

HRID 1820176

Reaktionsgleichung

Reaktionsgleichung von HRID 1820176
[C:1]([NH:9][CH:10]([C:15]([OH:17])=O)[CH2:11][CH2:12][S:13][CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2([OH:31])[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:21][CH:20]=1.C(NC(C(O)=O)C(C)C)(=O)C1C=CC=CC=1.Cl.ClC1C=CC(C2CCNCC2)=CC=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2([OH:31])[CH2:26][CH2:27][N:28]([C:15](=[O:17])[CH:10]([NH:9][C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:11][CH2:12][S:13][CH3:14])[CH2:29][CH2:30]2)=[CH:21][CH:20]=1

Komponenten

5

Edukt 4

HCID 382824-(4-Chlorophenyl)-4-hydroxypiperidineHCID 2266823-Methyl-2-(phenylformamido)butanoic acidHCID 295480Benzoyl-dl-methionineHCID 27578434-(4-chlorophenyl)piperidine Hydrochloride

Produkt 1

HCID 57889006N-(1-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-4-(methylthio)-1-oxobutan-2-yl)benzamide

Versuchsvorschrift

Example 217 was prepared in a similar manner as described for the preparation of Example 208 with the exceptions that benzoyl-DL-methionine and 4-(4-chlorophenyl)-4-hydroxypiperidine were substituted for benzoyl-DL-valine and 4-(4-chlorophenyl)piperidine hydrochloride, respectively. MS found: (M+H)+=448.

Aufarbeitung

  1. customExample 217 was prepared in a similar manner

Quellen und Nachweise

ORD-Eintrag
ord-54dde8d92b244532a474e24aaaae48ed
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07601844B2

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