Benzoyl chloride → N-(p-acetylphenyl)acetamide

HRID 18204

Reaktionsgleichung

Reaktionsgleichung von HRID 18204
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][CH:5]=1)=[O:3].[C:11](Cl)(=[O:18])[C:12]1C=CC=CC=1>ClCCl>[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([CH3:12])=[O:18])=[CH:6][CH:5]=1)=[O:3]

Komponenten

4

Edukt 2

HCID 7412Benzoyl chlorideHCID 7468p-Aminoacetophenone

Produkt 1

HCID 75937N-(p-acetylphenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Aminoacetophenone (1.35 g, 10.0 mmol) was dissolved in dichloromethane (10 mL) and treated with benzoyl chloride (1.74 mL, 15.0 mmol). The mixture was stirred for 16 hours at which time a white precipitate had formed. The solid was removed by filtration, washing with dichloromethane (3×20 mL) to provide 4-acetamidoacetophenone as a white sold (2.74 g). 1H NMR (200 MHz, DMSO-d6) δ 10.53 (s, 1H), 7.92 (s, 7H), 7.54 (m, 3H), 2.50 (s, 3H).

Aufarbeitung

  1. customhad formed
  2. customThe solid was removed by filtration
  3. washwashing with dichloromethane (3×20 mL)

Quellen und Nachweise

ORD-Eintrag
ord-a2ab303d98f44c96ab332b2033caec4b
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741349B2

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