HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Butyl bromide → (2-Butoxy-5-nitro-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Butyl bromide | HCID 8002 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | (2-Hydroxy-5-nitro-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone | HCID 69036826 | — |
| Lösungsmittel | Dimethylacetamide | HCID 31374 | — |
| Produkt | (2-Butoxy-5-nitro-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone | HCID 69037226 | — |
Reaktionsschritte
A solution of (2-Hydroxy-5-nitro-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (50 mg), potassium carbonate (87 mg) and 1-bromobutane (0.15 mL) in dimethylacetamide (0.3 mL) was heated at 150° C. for 15 minutes in a microwave oven. The reaction mixture was then concentrated and purified by column chromatography (SiO2) to give the title compound (55 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07605163B2 |
| Quelldatensatz | uspto-grants-2009_10 |
| ORD ID | ord-489ed2af0ea6480595056d6fd8c2ca20 |
| Quellennotiz | uspto-grants-2009_10 |