1-[2-Fluoro-4-(methylsulfonyl)phenyl]piperazine → (2-Benzyloxy-5-methanesulfonyl-phenyl)-[4-(2-fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-methanone

HRID 1820833Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1820833
[F:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[CH2:18]([O:25][C:26]1[CH:34]=[CH:33][C:32]([S:35]([CH3:38])(=[O:37])=[O:36])=[CH:31][C:27]=1[C:28](O)=[O:29])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:25][C:26]1[CH:34]=[CH:33][C:32]([S:35]([CH3:38])(=[O:37])=[O:36])=[CH:31][C:27]=1[C:28]([N:15]1[CH2:16][CH2:17][N:12]([C:3]2[CH:4]=[CH:5][C:6]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:7][C:2]=2[F:1])[CH2:13][CH2:14]1)=[O:29])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Komponenten

3

Edukt 2

HCID 27827301-[2-Fluoro-4-(methylsulfonyl)phenyl]piperazineHCID 688266832-Benzyloxy-5-methanesulfonyl-benzoic acid2×

Produkt 1

HCID 69037318(2-Benzyloxy-5-methanesulfonyl-phenyl)-[4-(2-fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-methanone

Versuchsvorschrift

The title compound was prepared in analogy to example 5 from 1-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazine (commercial) and 2-Benzyloxy-5-methanesulfonyl-benzoic acid (compound 7.5). MS (m/e): 547.4 (MH+, 100%)

Quellen und Nachweise

ORD-Eintrag
ord-70e23f77577440fe9a44e3ce3bd58b68
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07605163B2

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