3-(3,4-dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine → [3-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolo[2,3-b]pyridin-1-yl]-[2-(2,2,2-trifluoro-ethoxy)-naphthalen-1-yl]-methanone

HRID 1820900

Reaktionsgleichung

Reaktionsgleichung von HRID 1820900
COC1C=C(C2C3C(=NC=CC=3)NC=2)C=CC=1OC.[F:20][C:21]([F:38])([F:37])[CH2:22][O:23][C:24]1[CH:33]=[CH:32][C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]=1[C:34]([OH:36])=O.[CH:39]1([O:44][C:45]2[CH:46]=[C:47]([C:53]3[C:61]4[C:56](=[N:57][CH:58]=[CH:59][CH:60]=4)[NH:55][CH:54]=3)[CH:48]=[CH:49][C:50]=2[O:51][CH3:52])[CH2:43][CH2:42][CH2:41][CH2:40]1>>[CH:39]1([O:44][C:45]2[CH:46]=[C:47]([C:53]3[C:61]4[C:56](=[N:57][CH:58]=[CH:59][CH:60]=4)[N:55]([C:34]([C:25]4[C:26]5[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=5)[CH:32]=[CH:33][C:24]=4[O:23][CH2:22][C:21]([F:20])([F:38])[F:37])=[O:36])[CH:54]=3)[CH:48]=[CH:49][C:50]=2[O:51][CH3:52])[CH2:40][CH2:41][CH2:42][CH2:43]1

Komponenten

4

Edukt 3

HCID 116732853-(3,4-dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridineHCID 435056142-(2,2,2-Trifluoro-ethoxy)-naphthalene-1-carboxylic acidHCID 578916763-[3-(Cyclopentyloxy)-4-methoxyphenyl]-1H-pyrrolo[2,3-b]pyridine

Produkt 1

HCID 57891726[3-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolo[2,3-b]pyridin-1-yl]-[2-(2,2,2-trifluoro-ethoxy)-naphthalen-1-yl]-methanone

Versuchsvorschrift

[3-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolo[2,3-b]pyridin-1-yl]-[2-(2,2,2-trifluoro-ethoxy)-naphthalen-1-yl]-methanone 124 was prepared using the same protocol as described in Example 47, substituting 2-ethoxy-4-nitro-benzoic acid and 3-(3,4-Dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine with 2-(2,2,2-Trifluoro-ethoxy)-naphthalene-1-carboxylic acid and 3-(3-cyclopentoxy-4-methoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine. MS(ESI) [M+H+]+=561.10.

Quellen und Nachweise

ORD-Eintrag
ord-02950d1733bb4aa38d1fc2e6a9354450
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07605168B2

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