Isonicotinoyl chloride hydrochloride → HCID 69066449, Verbindung
Reaktionsgleichung
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[N:14]=[C:13]([NH2:15])[CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.Cl.[C:17]([Cl:25])(=[O:24])[C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1>>[ClH:25].[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([O:8][C:9]2[N:14]=[C:13]([NH:15][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)[CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:7]1Komponenten
3
Versuchsvorschrift
Using a method similar to example 160 using 6-(1-methyl-piperidin-4-yloxy)-pyridin-2-ylamine (preparation 60, 150 mg, 0.724 mmol) and isonicotinoyl chloride hydrochloride (192 mg, 1.08 mmol) yields the title compound (225 mg, 89%). Mass spectrum (ion spray): m/z 313.1 (M+1); Analysis calculated for C17H21N4O2Cl.0.2H2O. Theory: C, 57.93; H, 6.12; N, 15.90. Found: C, 57.78; H, 6.28; N, 15.88. mp=254-256° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-8c466562efdd47caa8be1e1c9aa8d3ec
- Quelldatensatz
- uspto-grants-2009_10