Bromopyruvic Acid → 2-(Isopropylamino)thiazole-4-carboxylic acid hydrobromide

HRID 1822458Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1822458
[CH:1]([NH:4][C:5]([NH2:7])=[S:6])([CH3:3])[CH3:2].[Br:8][CH2:9][C:10](=O)[C:11]([OH:13])=[O:12]>O1CCOCC1>[BrH:8].[CH:1]([NH:4][C:5]1[S:6][CH:9]=[C:10]([C:11]([OH:13])=[O:12])[N:7]=1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 70684Bromopyruvic AcidHCID 1711921Urea, 1-isopropyl-2-thio-

Produkt 1

HCID 119534892-(Isopropylamino)thiazole-4-carboxylic acid hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A suspension of compound 45 (2.1 g, 18 mmol) and 3-bromopyruvic acid (3.0 g, 18 mmol) in dioxane (180 mL) was heated to 80° C. Upon reaching 80° C. the mixture became clear, and soon thereafter the product started to precipitate as a white solid. After 2 h of heating, the reaction mixture was cooled to rt and the precipitate was filtered off and collected. This yielded pure compound 46 (4.4 g, 94%).

Aufarbeitung

  1. customUpon reaching 80° C.
  2. customto precipitate as a white solid
  3. temperatureAfter 2 h of heating
  4. temperaturethe reaction mixture was cooled to rt
  5. filtrationthe precipitate was filtered off
  6. customcollected

Quellen und Nachweise

ORD-Eintrag
ord-f36b677243d844e9a45de9943467dee4
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07608590B2

Notizen zur Reaktion

Wird geladen…