Methylamine → 5-Oxo-pyrrolidine-3-carboxylic acid methylamide

HRID 1823021Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1823021
[O:1]=[C:2]1[NH:6][CH2:5][CH:4]([C:7]([OH:9])=O)[CH2:3]1.CN.[CH3:12][N:13](C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[CH3:12][NH:13][C:7]([CH:4]1[CH2:3][C:2](=[O:1])[NH:6][CH2:5]1)=[O:9]

Komponenten

4

Edukt 3

HCID 6329MethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 167851365-Oxopyrrolidine-3-carboxylic acid

Produkt 1

HCID 552206635-Oxo-pyrrolidine-3-carboxylic acid methylamide

Versuchsvorschrift

In an analogous manner to that described in Example 24f), by condensing (R)-1-(4-benzyloxy)-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid with methylamine using HBTU as the condensation agent there is obtained (R)-1-(4-benzyloxy)-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methylamide as a white solid. MS: m/e=325 (M+H)+; [α]589=−27.55° (c=0.958, CH2Cl2).

Quellen und Nachweise

ORD-Eintrag
ord-e421d638fa094c4d8fc46b4ca6306a1e
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07037935B2

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