2-Imidazoline → 1-(4-Ethylphenyl)-2-imidazolylethan-1-one

HRID 1823452

Reaktionsgleichung

Reaktionsgleichung von HRID 1823452
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][CH:6]=1)=[O:4].[NH:13]1[CH2:17][CH2:16][N:15]=[CH:14]1>C(#N)C>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][C:14]2[NH:13][CH:17]=[CH:16][N:15]=2)=[CH:6][CH:7]=1)[CH3:12]

Komponenten

4

Edukt 2

HCID 681562-ImidazolineHCID 124019512-Bromo-1-(4-ethylphenyl)ethan-1-one

Produkt 1

HCID 221425781-(4-Ethylphenyl)-2-imidazolylethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

1 mmol of 2-bromo-1-(4-ethylphenyl)ethan-1-one in acetonitrile was added drop wise to 5.5 mmol imidazoline in acetonitrile at room temperature for fourteen hours. The reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The solution was extracted three times with ethyl acetate and dried over sodium sulfate to obtain 1-(4-ethylphenyl)-2-imidazolylethan-1-one.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water and ethyl acetate
  3. extractionThe solution was extracted three times with ethyl acetate
  4. dry with materialdried over sodium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-f9f5a92ea9be466096af4acb0a9610f2
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07037918B2

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