Potassium Carbonate → 6-Chloro-2-dimethylamino-3-nitropyridine

HRID 1823496

Reaktionsgleichung

Reaktionsgleichung von HRID 1823496
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:18][NH:19][CH3:20].O1CCCC1>O1CCCC1>[Cl:11][C:4]1[N:3]=[C:2]([N:19]([CH3:20])[CH3:18])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 852392,6-Dichloro-3-nitropyridineHCID 22320367Dimethylamine tetrahydrofuran

Produkt 1

HCID 217876256-Chloro-2-dimethylamino-3-nitropyridineAusbeute 52,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 2,6-dichloro-3-nitropyridine (1.9 g, 10 mmole) and potassium carbonate (1.66 g, 12 mmole) in 30 ml of tetrahydrofuran was stirred at 0° C. for 5 min. A solution of dimethylamine/tetrahydrofuran (2M, 6 ml, 12 mmole) was added dropwise to the reaction mixture over 40 min. After stirring for 5 min at 0° C., the mixture was warmed to room temperature and stirred overnight. The reaction mixture was filtered and the filtrate was collected and concentrated under reduced pressure. The crude product was purified by flash chromatography, eluting with 87% hexane: 13% ethyl acetate to give 6-chloro-2-dimethylamino-3-nitro pyridine (1.05 g).

Aufarbeitung

  1. stirringAfter stirring for 5 min at 0° C.
  2. temperaturethe mixture was warmed to room temperature
  3. stirringstirred overnight
  4. filtrationThe reaction mixture was filtered
  5. customthe filtrate was collected
  6. concentrationconcentrated under reduced pressure
  7. customThe crude product was purified by flash chromatography
  8. washeluting with 87% hexane

Quellen und Nachweise

ORD-Eintrag
ord-8a881d32c803434bb24c25a0630a3199
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07037918B2

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