8-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine → 3,6-diethyl-N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

HRID 1824142Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1824142
[CH2:1]([C:3]1[C:4](N[C@@H]2C3C(=CC=CC=3)C[C@@H]2O)=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2].[CH3:22][O:23][C:24]1[CH:25]=[CH:26][CH:27]=[C:28]2[C:33]=1[CH:32]([NH2:34])[CH2:31][CH2:30][CH2:29]2>>[CH2:1]([C:3]1[C:4]([NH:34][CH:32]2[C:33]3[C:28](=[CH:27][CH:26]=[CH:25][C:24]=3[O:23][CH3:22])[CH2:29][CH2:30][CH2:31]2)=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2]

Komponenten

3

Edukt 2

HCID 221473568-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amineHCID 58583341(1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

Produkt 1

HCID 221473163,6-diethyl-N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

Versuchsvorschrift

Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 8-methoxy-1,2,3,4-tetrahydronaphthalen-1-amine and making non-critical variations provided the title compound as a oil: 1H NMR (300 MHz, CDCl3) δ) 7.63, 7.22, 6.78, 5.40, 4.31, 3.71, 2.86–2.65, 2.53–2.38, 1.88–1.67, 1.32, 1.21; HRMS (FAB) calcd for C19H25N3O+H 312.2076, found 312.2077.

Quellen und Nachweise

ORD-Eintrag
ord-b6ce564aa5d74644943b56821b85b463
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07041672B2

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