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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1824504Erstellt: 26. Oktober 2026

2-Amino-4-methylpyridine → 2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide

https://huagongshe.com/reaction/1824504

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt2-Amino-4-methylpyridineHCID 1533—
Eduktalpha-Bromo-3'-methoxy-4'-chloropropoxyacetophenoneHCID 22015629—
LösungsmittelEthanolHCID 702—
Produkt2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromideHCID 2201559870,5%

Reaktionsschritte

A solution of the product of Step B (1.44 g) and 2-amino-4-picoline (0.486 g) in ethanol (6 mL) was heated at 73° C. for 1 hour. The reaction mixture was cooled to ambient temperature and evaporated to a yellow solid. The solid was stirred with 25 mL of dichloromethane for approximately 10 minutes. The mixture was filtered and the solid product collected to yield the title compound (1.3 g).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07041827B2
Quelldatensatzuspto-grants-2006_05
ORD IDord-11c85a8ee7884795a73a6fb9892f0127
Quellennotizuspto-grants-2006_05