2-Amino-4-methylpyridine → 2-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine

HRID 1824509

Reaktionsgleichung

Reaktionsgleichung von HRID 1824509
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1>C(O)C>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:12]=[C:13]3[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]3[CH:2]=2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 15332-Amino-4-methylpyridineHCID 74544-Bromophenacyl bromide

Produkt 1

HCID 7176442-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridineAusbeute 56,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2,4′-dibromoacetophenone (22.4 g) and 2-amino-4-picoline (8.68 g) in ethanol (80 mL) was heated at reflux temperature for 3 hours. The reaction mixture was cooled to ambient temperature and the crystalline solid isolated by filtration, washed with ethanol and dried in vacuo to give the title compound (13.1 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux temperature for 3 hours
  3. customthe crystalline solid isolated by filtration
  4. washwashed with ethanol
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5bb051e282244be59cd34ecde14aabce
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07041827B2

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