2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine → 2-[4-(2-Hydroxy-3-propylaminopropoxy)phenyl]-8-methylimidazo[1,2-a]pyridine

HRID 1824520

Reaktionsgleichung

Reaktionsgleichung von HRID 1824520
[O:1]1[CH2:21][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]3[CH:20]=2)=[CH:7][CH:6]=1>C(N)CC>[OH:1][CH:2]([CH2:21][NH:12][CH2:11][CH2:8][CH3:7])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]3[CH:20]=2)=[CH:7][CH:6]=1

Komponenten

3

Edukt 1

HCID 220156322-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

Produkt 1

HCID 220156042-[4-(2-Hydroxy-3-propylaminopropoxy)phenyl]-8-methylimidazo[1,2-a]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7852PropylamineLösungsmittel

Versuchsvorschrift

The product of Step C (5.0 g) and propylamine (20 mL) was heated at 40° C. for 18 hours. The reaction was cooled to ambient temperature evaporated and the residue purified via silica gel chromatography (dichloromethane/methanol) to give the title compound which was converted to a HCl salt upon treatment with HCl/methanol.

Aufarbeitung

  1. customevaporated
  2. customthe residue purified via silica gel chromatography (dichloromethane/methanol)

Quellen und Nachweise

ORD-Eintrag
ord-f198561756424430a43158144f48008b
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07041827B2

Verknüpfte Notizen

Wird geladen…