Phosphorus oxychloride → HCID 11196721, Verbindung

HRID 1824720

Reaktionsgleichung

Reaktionsgleichung von HRID 1824720
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](O)[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:21])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([Cl:21])[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 178517489HCID 178517489, Verbindung

Produkt 1

HCID 11196721HCID 11196721, Verbindung

Versuchsvorschrift

8.0 g of 2-(4-chlorophenyl)-4-hydroxy-5,6,7,8-tetrahydroquinazoline were heated to 100° C. in 10 ml of phosphorus oxychloride. After 3 hours, the cooled solution was carefully poured onto ice water. The crystalline product was filtered off with suction, washed well with water and dried in vacuo at room temperature. Yield: 6.2 g; m.p.: 121° C.

Aufarbeitung

  1. additionthe cooled solution was carefully poured onto ice water
  2. filtrationThe crystalline product was filtered off with suction
  3. washwashed well with water
  4. customdried in vacuo at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-17378f48516545b6a8122404210c0143
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07045526B2

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