Ethylenediamine → (2-Aminoethyl)[5-(trifluoromethyl)(2-pyridyl)]amine

HRID 1825431

Reaktionsgleichung

Reaktionsgleichung von HRID 1825431
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][N:3]=1.[CH2:12]([NH2:15])[CH2:13][NH2:14]>>[NH2:14][CH2:13][CH2:12][NH:15][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 3301EthylenediamineHCID 923422-Chloro-5-(trifluoromethyl)pyridine

Produkt 1

HCID 2779424(2-Aminoethyl)[5-(trifluoromethyl)(2-pyridyl)]amine

Versuchsvorschrift

2-Chloro-5-(trifluoromethyl)pyridine (5.0 g) was heated with ethylenediamine (20 ml) at 120° C. overnight. The excess ethylenediamine was removed by rotary evaporation and the residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide. The aqueous layer was extracted 5 times further with dichloromethane. The combined organic layers were washed with a saturated aqueous sodium chloride solution, dried, then concentrated in vacuo to give (2-aminoethyl)[5-(trifluoromethyl)(2-pyridyl)]amine as an orange oil.

Aufarbeitung

  1. customThe excess ethylenediamine was removed by rotary evaporation
  2. customthe residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide
  3. extractionThe aqueous layer was extracted 5 times further with dichloromethane
  4. washThe combined organic layers were washed with a saturated aqueous sodium chloride solution
  5. customdried
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9627b927e2684afb91ac8ea9d4e6ca1f
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07045519B2

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