Ngx-267 → (R)-2-Ethyl-8-methyl-1-thia-4,8-diaza-spiro[4.5]decan-3-one

HRID 1825845Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1825845
[CH3:1][CH2:2][C@@H:3]1[S:8][C:7]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[NH:6][C:4]1=[O:5]>C1CCCCC1>[CH2:2]([C@@H:3]1[C:4](=[O:5])[NH:6][C:7]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[S:8]1)[CH3:1]

Komponenten

3

Edukt 1

HCID 10013505Ngx-267

Produkt 1

HCID 11694209(R)-2-Ethyl-8-methyl-1-thia-4,8-diaza-spiro[4.5]decan-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8078CyclohexaneLösungsmittel

Versuchsvorschrift

The obtained (R)-2-mercaptobutyric acid was purified by distillation and then reacted with ammonium acetate and 1-methyl-4-piperidone in boiling cyclohexane. The crude reaction mixture was analyzed by GC on a chiral column and found to contain AF267A accompanied by a small (2–3%) amount of AF267B.

Aufarbeitung

  1. distillationThe obtained (R)-2-mercaptobutyric acid was purified by distillation
  2. customreacted with ammonium acetate and 1-methyl-4-piperidone
  3. customThe crude reaction mixture

Quellen und Nachweise

ORD-Eintrag
ord-48e22892c0c84f428ffb971ff5eac8e7
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07049321B2

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