1,3-dimethyl-1H-indole-2-carbaldehyde → 1-Ethyl-5-fluoro-3-(methylaminomethyl)-1H-indole
Reaktionsgleichung
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[CH2:14]([N:16]1[C:24]2[C:19](=[CH:20][C:21]([F:25])=[CH:22][CH:23]=2)[C:18]([CH:26]=O)=[CH:17]1)[CH3:15].CN1C2C(=CC=CC=2)C(C)=C1C=O>>[CH2:14]([N:16]1[C:24]2[C:19](=[CH:20][C:21]([F:25])=[CH:22][CH:23]=2)[C:18]([CH2:26][NH:6][CH3:5])=[CH:17]1)[CH3:15]Komponenten
4
Versuchsvorschrift
According to the procedure of Preparation 11 (c), except substituting 1-ethyl-5-fluoro-1H-indole-3-carboxaldehyde (0.2 g,1.9 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.1 g, 50%) was prepared as a viscous oil: MS (ES) m/e 207 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-fe069391ddc647c59b9c5bea99caa8f8
- Quelldatensatz
- uspto-grants-2006_05
- Patentnummer
- US07049310B2
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