Triphenylphosphine → 4-(5-Undecyl-pyrimidin-2-yl)phenyl (3-ethyl-cyclopentan-1-yl)methyl ether

Beteiligte Stoffe

Reaktionsschritte

A fully reacted mixture of equimolar amounts of diethyl azodicarboxylate and triphenylphosphine in THF is admixed with equimolar amounts of 4-(5-undecyl-pyrimidin-2-yl)phenol and 3-ethyl-cyclopentan-1-yl-methanol (prepared by LiAlH4 reduction of methyl 3-ethyl-cyclopentanecarboxylic acid). The mixture is stirred for 24 h at room temperature and then evaporated to dryness under reduced pressure. Purification by chromatography (silica gel, dichloromethane) and recrystallization affords the target compound.

Herkunft & Nachweise