Trifluoroacetic acid → 4-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine

HRID 1827218Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1827218
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[C:21]([O:22][CH3:23])=[N:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[CH3:23][O:22][C:21]1[C:16]([NH:15][CH2:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:17][CH:18]=[CH:19][N:20]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 235773124-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 221357494-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine

Versuchsvorschrift

4-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (0.5 g, 0.0015 mol) and trifluoroacetic acid (5 mL) were allowed to stir under nitrogen for 0.5 h. The reaction was concentrated in vacuo, and chromatographed on silica using methylene chloride/methanol/ammonium hydroxide (90/10/2) to give the title compound. M.S.(M+1): 223.

Aufarbeitung

  1. concentrationThe reaction was concentrated in vacuo
  2. customchromatographed on silica

Quellen und Nachweise

ORD-Eintrag
ord-2aba8244aeb54bb087df51994525aab6
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07053089B2

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