Phenothiazine → 9-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]phenothiazine

HRID 1827712Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1827712
NC1N=C(N)C2C(CN(C3C=CC=CC=3)C3C=CC=CC=3)=CSC=2N=1.[NH2:26][C:27]1[N:28]=[C:29]([NH2:37])[C:30]2[C:35]([CH3:36])=[CH:34][S:33][C:31]=2[N:32]=1.[CH:38]1[C:51]2[NH:50][C:49]3[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=3)[S:43][C:42]=2[CH:41]=[CH:40][CH:39]=1>>[NH2:26][C:27]1[N:28]=[C:29]([NH2:37])[C:30]2[C:35]([CH2:36][C:48]3[CH:47]=[CH:46][CH:45]=[C:44]4[C:49]=3[NH:50][C:51]3[CH:38]=[CH:39][CH:40]=[CH:41][C:42]=3[S:43]4)=[CH:34][S:33][C:31]=2[N:32]=1

Komponenten

4

Edukt 3

HCID 7108PhenothiazineHCID 9906281n-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]-n,n-diphenylamineHCID 12659534Thieno[2,3-d]pyrimidine-2,4-diamine, 5-methyl-

Produkt 1

HCID 220630199-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]phenothiazine

Versuchsvorschrift

9-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]phenothiazine (Formula I: Ar=2,4-diaminothieno[2,3-d]pyrimidin-5-yl; W=CH2; X=N; Z=S; m=n=0) is prepared similarly to N-[(2,4-diaminothieno[2,3-d]pyrimidin-5-yl)methyl]-N,N-diphenylamine as disclosed in Example 11 above by using 2,4-diamino-5-methylthieno[2,3-d]pyrimidine (1.3 g, 7.4 mmol) in Step 1 and phenothiazine (159 mg, 0.8 mmol) in Step 3. The final product and its intermediates can be purified by chromatography.

Aufarbeitung

  1. customThe final product and its intermediates can be purified by chromatography

Quellen und Nachweise

ORD-Eintrag
ord-fe20ee7f059d456c93876ee6f0635ffe
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07056911B1

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