Sodium Cyanide → 4-Amino-4-cyano-1,2-dimethyl-piperidine

HRID 1827824Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1827824
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=O)[CH2:4][CH:3]1[CH3:9].[C-:10]#[N:11].[Na+].[NH4+:13].[Cl-]>N.CO>[NH2:13][C:5]1([C:10]#[N:11])[CH2:6][CH2:7][N:2]([CH3:1])[CH:3]([CH3:9])[CH2:4]1

Komponenten

6

Edukt 3

HCID 8929Sodium CyanideHCID 25517Ammonium ChlorideHCID 124240391,2-Dimethylpiperidin-4-one

Produkt 1

HCID 220631094-Amino-4-cyano-1,2-dimethyl-piperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 222AmmoniaLösungsmittel2×HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

1,2-Dimethyl-4-piperidone (1.23 g, 9.67 mmol, 1.0 equiv) was dissolved in 39 mL of 2 M NH3 in MeOH (8 equiv NH3). To this solution was added NaCN (0.52 g, 10.6 mmol, 1.1 equiv) and NH4Cl (0.57 g, 10.6 mmol, 1.1 equiv). The resulting mixture was refluxed for 2 h at which time an additional 39 mL of 2 M NH3 in MeOH was added followed by an additional 2 h of reflux. The reaction was cooled and filtered. The filtrate was concentrated and taken up in 100 mL of CH2Cl2 giving more salt precipitate which was removed by a second filtration. The filtrate was then concentrated to thick orange oil (1.32 g, 89%). 1H NMR showed a 3 to 1 mixture of diastereomers of unknown configuration. The crude product was used without further purification; MS, m/z 154=M+1.

Aufarbeitung

  1. additionwas added
  2. temperatureof reflux
  3. temperatureThe reaction was cooled
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated
  6. customwas removed by a second filtration
  7. concentrationThe filtrate was then concentrated to thick orange oil (1.32 g, 89%)
  8. additionto 1 mixture of diastereomers of unknown configuration
  9. customThe crude product was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-4f77ba2e377f4cfda05945f93f32caa9
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07056915B2

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