Methyl (R)-(+)-2-isocyanato-3-phenylpropionate → (R)-2-(4-Phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester

Beteiligte Stoffe

Reaktionsschritte

(4-Phenethyloxyphenyl)methanol 11(1.141 g, 5.0 mmol), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.036 g, 5.0 mmol) and DMAP (10 mg) were combined and heated until molten and stirred for 20 min. Upon cooling the residue was purified by chromatography to give about 2.1 g of (R)-2-(4-phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic acid methyl ester 12.

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