4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine → 8-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-hydroxy-3-[(4-methoxybenzyl)tetrazol-5-yl]-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 1828510Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1828510
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].[CH3:18][O:19][C:20]1[CH:42]=[CH:41][C:23]([CH2:24][N:25]2[C:29]([CH:30]([C:36](OCC)=[O:37])[C:31](OCC)=[O:32])=[N:28][N:27]=[N:26]2)=[CH:22][CH:21]=1>BrC1C=CC=CC=1>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]3[C:31](=[O:32])[C:30]([C:29]4[N:25]([CH2:24][C:23]5[CH:41]=[CH:42][C:20]([O:19][CH3:18])=[CH:21][CH:22]=5)[N:26]=[N:27][N:28]=4)=[C:36]([OH:37])[N:17]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 220636524-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridineHCID 22063755Diethyl 2-[1-(4-methoxybenzyl)tetrazol-5-yl]malonate

Produkt 1

HCID 1357244388-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-hydroxy-3-[(4-methoxybenzyl)tetrazol-5-yl]-4H-pyrido[1,2-a]pyrimidin-4-oneAusbeute 71,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7961BromobenzeneLösungsmittel

Versuchsvorschrift

4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine (50 mg) and diethyl 2-[1-(4-methoxybenzyl)tetrazol-5-yl]malonate (141 mg) were heated to 150° C. in bromobenzene with stirring for 4 hours. After the solvent was evaporated, the residue was purified by silica gel column chromatography to obtain the title compound (73 mg) as cream solid.

Aufarbeitung

  1. customAfter the solvent was evaporated
  2. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e16a421f5eee48ed99d233754d116ddb
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07056917B2

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