Bromobenzene → ethyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate

HRID 1828514Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1828514
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].CN([CH:21]=[C:22]([C:30](OCC)=[O:31])[CH:23]=[CH:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])C.BrC1C=CC=CC=1>>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]3[C:30](=[O:31])[C:22](/[CH:23]=[CH:24]/[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:21][N:17]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 3

HCID 7961BromobenzeneHCID 220636524-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridineHCID 54366534Diethyl 1-dimethylamino-1,3-butadiene-2,4-dicarboxylate

Produkt 1

HCID 86588142ethyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoateAusbeute 6,2 %

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine(200 mg), diethyl 4-dimethylaminomethyleneglutaconate (265 mg) was added with bromobenzene (2 ml) and heated at 120° C. for 1 hour and at 160° C. for 4 hours with stirring. The residue was purified by silica gel column chromatography to obtain the title compound (20 mg) as white powder.

Aufarbeitung

  1. customThe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-8e1ee26a48b34949bd410e20598ecf71
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07056917B2

Notizen zur Reaktion

Wird geladen…