tert-Butyl isocyanate → N-(t-Butyl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide

HRID 1828595

Reaktionsgleichung

Reaktionsgleichung von HRID 1828595
[C:1]([N:5]=[C:6]=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[CH:17][N:18]([CH3:28])[C:19]=2[C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=2[Cl:27])=[CH:11][CH:10]=1>>[C:1]([NH:5][C:6]([C:17]1[N:18]([CH3:28])[C:19]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=2[Cl:27])=[C:15]([C:12]2[CH:13]=[CH:14][C:9]([Cl:8])=[CH:10][CH:11]=2)[N:16]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 62412tert-Butyl isocyanateHCID 220660834-(4-Chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole

Produkt 1

HCID 10274740N-(t-Butyl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide

Versuchsvorschrift

Using essentially the same procedure as Example 33, but using t-butyl isocyanate (0.040 mL, 0.30 mmol), 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole (50 mg, 0.15 mmol) from Example 32, Step C was converted to the title compound after purification by Prep TLC (25% ethyl acetate in hexanes).

Quellen und Nachweise

ORD-Eintrag
ord-145c8e0664b54a158a7b5330c06eef8c
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07057051B2

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