1-Indanone → 1-(1H-Inden-3-yl)pyrrolidine

HRID 1828845Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1828845
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:6]1(=O)[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7]1>[Ti](Cl)(Cl)(Cl)Cl.CCCCC>[C:8]1([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 67351-IndanoneHCID 31268Pyrrolidine

Produkt 1

HCID 6039341-(1H-Inden-3-yl)pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 24193Titanium TetrachlorideKatalysatorHCID 8003PentaneLösungsmittel

Versuchsvorschrift

To a 100 ml reaction tube equipped with a stirrer bar, Suba.Seal™ stopper, and a nitrogen balloon, was added pyrrolidine (1.3 ml) and pentane (8 ml). Titanium tetrachloride (0.2 ml) was added slowly to each tube. 1-Indanone (0.2 g, 1.33 mmol) was added as a solid and the reaction stirred vigorously for 2 h. The reaction mixture was filtered through Celite and the solvent removed in vacuo to give the title compound as a dark solid. m/z (ES+) 186 (M+H)+.

Aufarbeitung

  1. customTo a 100 ml reaction tube
  2. customequipped with a stirrer bar
  3. filtrationThe reaction mixture was filtered through Celite
  4. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-82fda51d946a477fb33af1e6be592799
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07060710B2

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