HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
phenylalaninol, (S)- → (S)-N-[1-benzyl-2-hydroxyethyl]-4-hydroxy-1-methyl-1H-indole-2-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | phenylalaninol, (S)- | HCID 447213 | — |
| Edukt | 4-Benzyloxy-1-methyl-1H-indole-2-carbonyl chloride | HCID 22054872 | — |
| Produkt | (S)-N-[1-benzyl-2-hydroxyethyl]-4-hydroxy-1-methyl-1H-indole-2-carboxamide | HCID 69272852 | — |
| Produkt | (S)-N-[1-benzyl-2-hydroxyethyl]-4-(benzyloxy)-1-methyl-1H-indole-2-carboxamide | HCID 69276702 | — |
Reaktionsschritte
From (S)-2-amino-3-phenylpropan-1-ol and 4-benzyloxy-1-methyl-1H-indole-2-carbonyl chloride the intermediate compound (S)-N-[1-benzyl-2-hydroxyethyl]-4-(benzyloxy)-1-methyl-1H-indole-2-carboxamide was prepared by a method analogous to that described in Example 23. MS ES (M++H)=415. Hydrogenation of this intermediate by a method analogous to that described in Example 9 gave the title compound. MS ES (M++H)=325.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07064143B1 |
| Quelldatensatz | uspto-grants-2006_06 |
| ORD ID | ord-6bb9a43d536b46ce973f4a40981662f4 |
| Quellennotiz | uspto-grants-2006_06 |