Chloroform → HCID 178509715, Verbindung

HRID 1829867Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1829867
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:13]=[N:14][C:15]3[C:20]([CH:21]=2)=[N:19][CH:18]=[CH:17][CH:16]=3)([NH2:11])[CH2:9][NH2:10])=[CH:4][CH:3]=1.CO[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#N)[CH:27]=1)=[NH:25].C(Cl)(Cl)Cl>CO>[C:24]([C:26]1[CH:27]=[C:28]([C:32]2[NH:10][CH2:9][C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)([C:12]3[CH:13]=[N:14][C:15]4[C:20]([CH:21]=3)=[N:19][CH:18]=[CH:17][CH:16]=4)[N:11]=2)[CH:29]=[CH:30][CH:31]=1)#[N:25]

Komponenten

5

Edukt 3

HCID 6212ChloroformHCID 220548441-(4-Fluorophenyl)-1-(1,5-naphthyridin-3-yl)-1,2-ethanediamineHCID 552656943-Cyano-benzimidic acid methyl ester

Produkt 1

HCID 178509715HCID 178509715, VerbindungAusbeute 33,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1-(4-fluorophenyl)-1-(1,5-naphthyridin-3-yl)-1,2-ethanediamine (17 mg) in methanol (1 mL) was added 3-cyanobenzeneimidic acid methyl ester (23 mg), and the mixture was stirred at room temperature for 19 hrs. To the reaction mixture was added chloroform and insolubles were removed by filtration, followed by concentration of the filtrate in vacuo. The residue was purified by preparative thin-layer chromatography (100% ethyl acetate) to give the objective compound (8.0 mg).

Aufarbeitung

  1. customwere removed by filtration
  2. customThe residue was purified by preparative thin-layer chromatography (100% ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-9fa606034f484356be2bf943a8561e86
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07064142B2

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