Ethyl indole-2-carboxylate → Methyl N-methylindole-6-carboxylate

HRID 18302

Reaktionsgleichung

Reaktionsgleichung von HRID 18302
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1.N1C2C(=CC=CC=2)C=[C:15]1C(OCC)=O>>[CH3:15][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1

Komponenten

3

Edukt 2

HCID 73125Ethyl indole-2-carboxylateHCID 639844Methyl indole-6-carboxylate

Produkt 1

HCID 639843Methyl N-methylindole-6-carboxylateAusbeute 95 %

Versuchsvorschrift

According to the procedure of Preparation 9 (a), except substituting methyl indole-6-carboxylate for the ethyl indole-2-carboxylate, the title compound (2.5 g, 95%) was obtained as white solid: MS (ES) m/e 190.2 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-8dc5740280304c388f3887edea09d7f4
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741339B2

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