Ethanol → HCID 12084327, Verbindung

HRID 1830488Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1830488
[CH:1]([C:4]1[CH:16]=[CH:15][C:14]2[C:13]3[C:8](=[C:9]([F:17])[CH:10]=[CH:11][CH:12]=3)[CH2:7][C:6]=2[C:5]=1[F:18])=[CH:2][CH3:3].C(O)C>[C].[Pd].C1(C)C=CC=CC=1>[CH2:1]([C:4]1[CH:16]=[CH:15][C:14]2[C:13]3[C:8](=[C:9]([F:17])[CH:10]=[CH:11][CH:12]=3)[CH2:7][C:6]=2[C:5]=1[F:18])[CH2:2][CH3:3]

Komponenten

5

Edukt 2

HCID 702EthanolHCID 69530634HCID 69530634, Verbindung

Produkt 1

HCID 12084327HCID 12084327, VerbindungAusbeute 43,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 19.3 g of 2-(propen-1-yl)-1,8-difluorofluorene (K-3) (crude product), 1.5 g of 5% palladium-carbon, 80 ml of ethanol and 80 ml of toluene was hydrogenated over an 8 hour period at room temperature and under atmospheric pressure, with constant stirring. The palladium-carbon was removed by filtration, the solvent was removed from the filtrate by evaporation under reduced pressure, and the residue was then purified by silica gel column chromatography (hexane) to yield 8.5 g of 2-propyl-1,8-difluorofluorene (K-4).

Aufarbeitung

  1. customThe palladium-carbon was removed by filtration
  2. customthe solvent was removed from the filtrate by evaporation under reduced pressure
  3. customthe residue was then purified by silica gel column chromatography (hexane)

Quellen und Nachweise

ORD-Eintrag
ord-44b82ba1755b41a1aec090d99e648d21
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067179B1

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